Flow of microtubules in the Drosophila oocyte

Researchers: Martin Burger (University of Münster), Hendrik Dirks (previously University of Münster), Maik Drechsler, Lena Frerking (previously University of Münster), Sujoy Ganguly (previously University of Cambridge), Lukas Lang, Isabel Palacios, Carola-Bibiane Schönlieb

The focus of this project is to characterise directionality of plus ends of microtubules in confocal microscopy images of Drosophila embryos. This goal is particularly challenging due to the high noise level in such data, making it almost impossible to distinguish EB1 fluorescently labelled comets from randomly distributed noise. To overcome this problem we employ recently developed methods for joint motion estimation and image reconstruction, see e.g. Dirks (2015). As a result we are able to estimate motion in image sequences where other state of the art methods fail.

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