Research Associate in Preclinical Breast Cancer Imaging at University of York

Written by Rachel Furner
March 2, 2018

The University of York is looking for an enthusiastic postdoc to join a team of physiologists, chemists, MR physicists and radiologists on a translational breast cancer project funded by Cancer Research UK. The ionic composition of breast tumours, particularly sodium (Na+), is critical for regulating tumour growth, invasion and metastasis. Targeting the ionic microenvironment of breast tumours and combining such treatment with advanced 23Na-MR imaging represents a novel approach in the fight against breast cancer. In this project, you will investigate the mechanistic basis for Na+accumulation in breast tumours in mice using a combination of MRI, electrophysiology and fluorescence imaging, in order to establish the utility of Na+, and its conductance routes, as diagnostic indicators and therapeutic targets.

The postholder will conduct individual and collaborative research projects, duties to include: analysis and interpretation of research data; use of appropriate research techniques and methods; writing up of research results and dissemination through publications, seminar and conference presentations. You will implement protocols on a preclinical MRI scanner for 23Na breast cancer imaging in mice bearing xenografts. You will test the involvement of Na+ transporters in regulating tumour Na+ by treating mice with specific inhibiting drugs and neoadjuvant chemotherapy. You will also monitor the effects of these treatments on other tumour properties using standard 1H-MRI, cellular electrophysiology and fluorescent Na+ dyes.

Skills, Experience & Qualification needed:

Essential: PhD in cancer biology or equivalent; knowledge of breast cancer biology and a range of research techniques and methodologies; highly developed written and oral communication skills, including writing up work for publication; ability to develop research objectives, projects and proposals; competency and experience of conducting individual and collaborative research; attention to detail and commitment to high quality; collaborative ethos; enthusiasm for research; Home Office Personal Licence.

Desirable: Knowledge of preclinical MRI and RF coil construction, cellular electrophysiology and mammalian in vivo cancer models; competency with animal husbandry and surgery; experience with tumour xenograft models, electrophysiology, fluorescence imaging.

The full advert, and details of how to apply can be found at

Note this position is in no way connected to the CMIH